Acetazolamide Treatment Prevents Redistribution of Astrocyte Aquaporin 4 after Murine Traumatic Brain Injury
AQP4 total protein levels increase in an in vitro trauma model. Primary rat astrocytes were subjected to a single stretch injury and then OGD for 0, 6, 12, 24, and 48 hours. (a) Representative western blot for AQP4 and an actin loading control. (b) Densitometry measurements from 4 separate independent western blots show increased AQP4 protein expression at 48 hours of OGD. Results are averages ± SEM. Significant differences were determined with one-way ANOVA followed by Tukey’s HSD test. p<0.01.
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