Research Article

Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells

Figure 1

Performance of rats in different groups in active avoidance learning (a) and in memory retention test ((b) and (c)). Note that AD rats had significant learning and memory deficit and deficits were decreased/normalized by treatment with NAC (both 50mg/kg and 100mg/kg). Control/sham versus AD: ∗∗∗, p<0.001; AD versus AD+NAC50 or AD versus AD+NAC100: ###, p<0.001 (One-way ANOVA, Bonferroni’s multiple comparison test, n=6 in all groups).

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