Research Article

Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells

Figure 9

Quantitative estimation of number of Iba1 positive reactive microglia in various regions of the hippocampus. In CA1, CA2, CA3, and CA4 regions 400μm length and in dentate gyrus (DG) 400μ2 area were selected for quantification. Note that, in all regions, the number of microglia was significantly increased in AD group compared to control group. Number of microglia decreased significantly in AD+NAC 50 and AD+NAC 100 compared to AD group. In CA2, CA3, and DG number of microglia significantly increased compared to control group. Values are expressed as mean ± SE. Control/sham versus AD: ∗∗∗, p<0.001; control/sham versus AD+NAC50; or control/sham versus AD+NAC100: $$$, p<0.001, AD versus AD+NAC 50/100: ###, p< 0.001 (one-way ANOVA, Bonferroni’s multiple comparison test, n=6 in all groups).