Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection

Figure 3

HCMV latency is established in myeloid progenitors and reactivation occurs following differentiation. HCMV latency can be established in pluripotent haematopoietic cells which can be differentiated upon specific stimuli into different cell types as shown. HCMV is primarily carried along the myeloid lineage [41, 46, 47] and not the lymphoid lineage [48]. However, whether HCMV is carried along the endothelial cell lineage is uncertain.