A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 19

Pharmacokinetic parameters of TA-III in rats following intragastric administration of timosaponins, timosaponins-Huangbai alkaloids 1 : 1 and 1 : 3 mixtures, (1.17 mg TA-III/kg body weight) [20].

Parameters	Timosaponins ()			Timosaponins-Huangbai alkaloids 1 : 1 (TA-III 1.17 mg/kg, )	Timosaponins-Huangbai alkaloids 1 : 3 (TA-III 1.17 mg/kg, )
	TA-III 0.59 mg/kg	TA-III 1.17 mg/kg	TA-III 2.34 mg/kg
(μg/L)	18.24 5.81	25.10 4.09	54.62 12.15	38.63 20.41	27.76 13.77
(h)	6.60 2.97	5.50 3.33	6.33 1.97	7.60 2.61	8.33 2.34
(h)	6.68 1.66	6.61 3.12	5.51 1.24	10.80 3.34	9.91 2.81
AUC (μg h/L)	180.5 64.4	248.5 62.6	505.8 155.2	633.8 313.2	434.9 223.3
AUC (μg h/L)	208.4 59.7	290.7 58.7	547.9 178.4	711.1 344.3	491.3 259.7
MRT (h)	12.18 1.13	12.54 3.44	10.33 1.47	18.01 3.60	17.30 2.94

< 0.05 versus oral administration of timosaponins (TA-III 1.17 mg/kg).