A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 21

Pharmacokinetic parameters of Escin Ia in rats after i.v. administration of the drug () [22].

Parameters	0.5 mg/kg	1.0 mg/kg	2.0 mg/kg
(ng/mL)	22807485	4362 1298	11,220 2330
(h)	7.5 2.1	9.6 1.9	12.2 1.7
AUC (ng h/mL)	10,036 4203	12,989 3101	29,156 6495
AUC (ng h/mL)	10,145 4270	13,185 3302	29,941 6753
CL (mL/min/kg)	4.82 2.13	6.05 1.95	5.81 1.30
(L/kg)	2.86 1.39	5.02 3.85	6.16 3.53
MRT (h)	5.46 1.54	5.39 0.880	6.29 1.16