New Journal of Science / 2016 / Article / Tab 25

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 25

Pharmacokinetic parameters of DS, RA, CT, DT, TI, and TII after oral dose of danshen extracts [25].

ParameterDSRACTDTTITII

(h)0.51 0.130.35 0.090.37 0.210.28 0.130.17 0.110.24 0.04
(h)0.89 0.160.54 0.110.69 0.180.54 0.140.94 0.360.40 0.04
(h) 3.04 1.283.68 0.412.81 0.393.65 1.744.72 1.903.70 0.65
(L/h)0.33 0.190.43 0.310.42 0.110.54 0.240.32 0.110.68 0.08
(L/h)0.66 0.070.92 0.070.62 0.0860.56 0.090.50 0.080.52 0.09
(L/h)0.10 0.080.38 0.200.26 0.120.46 0.180.26 0.340.81 0.09
(L/kg)0.07 0.020.18 0.070.13 0.020.33 0.170.06 0.0100.24 0.02
AUC (ng h/mL)220.67 52.5489.12 12.10123.40 8.0434.82 22.9169.64 32.2281.05 12.08
CL (L (kg/h))0.05 0.010.12 0.040.08 0.010.18 0.100.03 0.0020.14 0.01
(h)1.11 0.180.74 0.120.86 0.350.74 0.140.60 0.210.61 0.05
(ng/mL)71.98 22.8637.19 13.8542.85 13.5811.29 11.4954.64 17.7222.24 3.42
LOQ (ng/mL)50.750.10.110.5
LOD (ng/mL)2.50.380.050.050.50.1