A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 27

Pharmacokinetic parameters of oridonin, ponicidin, and rosmarinic acid after oral and i.v. administration to rats [27].

Pharmacokinetic parameters	Values (mean ± SD)
	Oridonin (IV)	Oridonin (PO)	Ponicidin (IV)	Ponicidin (PO)	Rosmarinic acid (IV)	Rosmarinic Acid (PO)
AUC (ng/mL/h)	932.81 ± 226.81	78.45 33.83	1,105.02 145.58	112.47 23.38	2,037.60 541.76	284.52 61.10
AUC (ng/mL/h)	980.74 287.15	79.29 34.26	1,132.83 165.29	120.00 19.61	2,059.44 546.25	313.51 75.24
MRT (h)	1.79 0.77	0.495 0.05	2.85 0.49	1.81 0.33	3.04 0.44	6.46 0.09
(h)	2.90 0.87	0.19 0.05	5.80 2.00	2.12 1.02	4.82 0.65	7.12 1.96
(h)	—	0.69 0.13	—	0.67 0.13	—	1.08 0.38
Clearance (L/h/kg)	1.08 0.31	13.99 4.27	0.90 0.14	8.54 1.52	1.28 0.40	0.07 0.02
(L/kg)	4.29 0.54	3.68 1.42	7.26 1.72	27.70 18.34	9.14 3.96	0.66 0.11
(ng/mL)	—	164.51 58.42	—	88.21 23.85	—	48.67 11.24
Bioavailability (%)	—	8.41 3.63	—	10.18 2.12	—	13.96 3.00