A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 28

Pharmacokinetic parameters of isocorydine in rats following i.v. (12.66 mg/kg) or i.g. (126.6 mg/kg) administration of D. scandens extract () [28].

Oral		Intravenous
Parameters	Values	Parameters	Values
(μg/L)	977 159	(μg/L)	2220 325
(h)	0.333 0.144	(h)	0.033 0
(h)	1.96 0.387	(h)	2.09 0.457
AUC (μg/L·h)	3629 697	AUC (μg/L×h)	1209 129
AUC (μg/L·h)	3697 677	AUC (μg/L×h)	1269 158
CL/ (L/h/kg)	5.52 0.924	CL (L/h/kg)	1.59 0.202
/ (L/kg)	16.0 5.32	(L/kg)	4.72 0.587
MRT (h)	3.08 0.354	MRT (h)	1.42 0.196
MRT (h)	3.31 0.272	MRT (h)	1.86 0.380
Zeta	0.363 0.080	Zeta	0.34 0.086
Bioavailability (%)	29.1	—	—