A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 29

Pharmacokinetic parameters of protopine in rats following i.v. (12.66 mg/kg) or i.g. (126.6 mg/kg) administration of D. scandens extract () [28].

Oral		Intravenous
Parameters	Values	Parameters	Values
(μg/L)	108 24.8	(μg/L)	131 24.1
(h)	2.67 1.16	(h)	0.033 0
(h)	2.61 0.739	(h)	2.43 0.737
AUC (μg/L·h)	598 53.0	AUC (μg/L×h)	170 23.7
AUC (μg/L·h)	635 60.9	AUC (μg/L×h)	246 35.5
CL/ (L/h/kg)	13.0 1.30	CL (L/h/kg)	3.36 0.450
/ (L/kg)	48.3 12.1	(L/kg)	25.7 4.62
MRT (h)	4.06 0.230	MRT (h)	2.66 0.094
MRT (h)	4.75 0.681	MRT (h)	6.70 0.534
Zeta	0.279 0.071	Zeta	0.132 0.010
Bioavailability (%)	25.8	—	—