Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 35
Pharmacokinetic parameters of arctiin after oral administration in rats (
) [
33].
| Pharmacokinetic parameter | Male | Female | 30 mg/kg | 50 mg/kg | 70 mg/kg | 30 mg/kg | 50 mg/kg | 70 mg/kg |
| (min) | 59.21 6.218 | 63.70 7.372 | 62.79 4.321 | 58.85 5.010 | 69.99 8.733 | 89.97 11.959 | (L/min) | 0.02 0.003 | 0.054 0.009 | 0.04 0.006 | 0.02 0.003 | 0.06 0.010 | 0.07 0.011 | / (L/kg) | 5.83 0.953 | 15.70 3.260 | 24.69 3.14 | 16.08 2.283 | 14.32 2.260 | 11.19 1.830 | CL/ (L/min/kg) | 0.07 0.008 | 0.153 0.024 | 0.26 0.034 | 0.13 0.026 | 0.29 0.079 | 0.41 0.062 | AUC (mg/L·min) | 98.77 9.78 | 111.17 13.074 | 130.77 6.728 | 112.25 10.820 | 134.29 21.313 | 168.08 23.249 | AUC (mg/L·min) | 131.17 7.23 | 146.16 15.050 | 177.67 19.005 | 145.09 10.751 | 175.01 26.106 | 205.67 19.964 | (L/min) | 0.059 0.005 | 0.07 0.009 | 0.100 0.006 | 0.13 0.013 | 0.12 0.014 | 0.14 0.004 | (mg/L) | 0.78 0.03 | 1.16 0.16 | 1.88 0.05 | 0.85 0.07 | 4.104 0.594 | 4.79 1.07 |
|
|
Significant () and significantly higher () than that of male rats.
|