Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 35

Pharmacokinetic parameters of arctiin after oral administration in rats () [33].

Pharmacokinetic parameterMaleFemale
30 mg/kg50 mg/kg70 mg/kg30 mg/kg50 mg/kg70 mg/kg

(min)59.21 6.21863.70 7.37262.79 4.32158.85 5.01069.99 8.73389.97 11.959
(L/min)0.02 0.0030.054 0.0090.04 0.0060.02 0.0030.06 0.0100.07 0.011
/ (L/kg)5.83 0.95315.70 3.26024.69 3.1416.08 2.28314.32 2.26011.19 1.830
CL/ (L/min/kg)0.07 0.0080.153 0.0240.26 0.0340.13 0.0260.29 0.0790.41 0.062
AUC (mg/L·min)98.77 9.78111.17 13.074130.77 6.728112.25 10.820134.29 21.313168.08 23.249
AUC (mg/L·min)131.17 7.23146.16 15.050177.67 19.005145.09 10.751175.01 26.106205.67 19.964
(L/min) 0.059 0.0050.07 0.0090.100 0.0060.13 0.0130.12 0.0140.14 0.004
(mg/L)0.78 0.031.16 0.161.88 0.050.85 0.074.104 0.5944.79 1.07

Significant () and significantly higher () than that of male rats.