Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 38

Pharmacokinetic parameters six lignans after oral administration of S. chinensis extract to rats (dose 7.5 g/kg) [36].

ParametersSchisandrinSchisandrol BSchisantherin ADeoxyshisandrin-SchisandrinGomisin N

Normal group
AUC (μg·h/L)15811 37741305 441.61654 359.42155 508.9682.3 229.51433 314.8
AUC (μg·h/L)16071 38091347 457.91730 408.42243 523.4700.5 228.51486 337.4
MRT (h) 10.93 1.0011.96 0.4812.09 2.2012.81 1.2210.89 0.7811.28 0.72
(h) 5.77 0.706.40 0.507.81 2.167.55 1.027.06 1.267.25 0.74
(h) 1.75 0.421.75 0.272.08 0.494.00 0.636.66 1.035.66 1.21
(μg/L)1542 329.4141.95 45.06141.2 25.15168.3 32.2273.58 16.83142.7 28.13
(L/kg/h)5.296 1.36813.52 5.5551.99 0.3814.26 4.17513.34 4.23022.79 6.030

Insomnic group
AUC (μg·h/L)22288 54521935 558.22261 506.72753 259.61486 458.71828 268.9
AUC (μg·h/L)23118 55322059 542.02475 502.43010 333.91598 526.61937 272.2
MRT (h) 12.67 1.3414.25 2.3415.51 2.2215.32 1.7613.49 1.4912.54 0.72
(h) 7.38 1.658.07 1.6810.77 3.519.77 2.409.17 1.758.98 2.55
(h)1.75 0.271.83 0.261.92 0.594.17 0.757.03 1.105.83 1.17
(μg/L)2284 227.4225.2 53.95202.8 24.77233.8 34.37125.1 20.51207.7 39.26
CL (L/kg/h)3.684 0.9538.349 2.2921.378 0.24210.14 1.0415.859 1.82616.95 2.646

compared with normal group (mean SD; ).