Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 38
Pharmacokinetic parameters six lignans after oral administration of
S. chinensis extract to rats (dose 7.5 g/kg) [
36].
| Parameters | Schisandrin | Schisandrol B | Schisantherin A | Deoxyshisandrin | -Schisandrin | Gomisin N |
| Normal group | AUC (μg·h/L) | 15811 3774 | 1305 441.6 | 1654 359.4 | 2155 508.9 | 682.3 229.5 | 1433 314.8 | AUC (μg·h/L) | 16071 3809 | 1347 457.9 | 1730 408.4 | 2243 523.4 | 700.5 228.5 | 1486 337.4 | MRT (h) | 10.93 1.00 | 11.96 0.48 | 12.09 2.20 | 12.81 1.22 | 10.89 0.78 | 11.28 0.72 | (h) | 5.77 0.70 | 6.40 0.50 | 7.81 2.16 | 7.55 1.02 | 7.06 1.26 | 7.25 0.74 | (h) | 1.75 0.42 | 1.75 0.27 | 2.08 0.49 | 4.00 0.63 | 6.66 1.03 | 5.66 1.21 | (μg/L) | 1542 329.4 | 141.95 45.06 | 141.2 25.15 | 168.3 32.22 | 73.58 16.83 | 142.7 28.13 | (L/kg/h) | 5.296 1.368 | 13.52 5.555 | 1.99 0.38 | 14.26 4.175 | 13.34 4.230 | 22.79 6.030 |
| Insomnic group | AUC (μg·h/L) | 22288 5452 | 1935 558.2 | 2261 506.7 | 2753 259.6 | 1486 458.7 | 1828 268.9 | AUC (μg·h/L) | 23118 5532 | 2059 542.0 | 2475 502.4 | 3010 333.9 | 1598 526.6 | 1937 272.2 | MRT (h) | 12.67 1.34 | 14.25 2.34 | 15.51 2.22 | 15.32 1.76 | 13.49 1.49 | 12.54 0.72 | (h) | 7.38 1.65 | 8.07 1.68 | 10.77 3.51 | 9.77 2.40 | 9.17 1.75 | 8.98 2.55 | (h) | 1.75 0.27 | 1.83 0.26 | 1.92 0.59 | 4.17 0.75 | 7.03 1.10 | 5.83 1.17 | (μg/L) | 2284 227.4 | 225.2 53.95 | 202.8 24.77 | 233.8 34.37 | 125.1 20.51 | 207.7 39.26 | CL (L/kg/h) | 3.684 0.953 | 8.349 2.292 | 1.378 0.242 | 10.14 1.041 | 5.859 1.826 | 16.95 2.646 |
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compared with normal group (mean SD; ).
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