A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 42

Pharmacokinetic parameters of salidroside and four samples, after i.v. and oral administration with dose of 50 mg/kg (12.5 mg/kg, i.e. 17.6 mL/kg for oral liquid) () [40].

Parameter	Standard salidroside; IV	Standard salidroside PO	R. crenulata PO	Tablet PO	Capsule PO	Oral liquid PO
(L/min)	0.0330 0.005	0.0128 0.012	0.0077 0.025	0.0111 0.0038	0.0108 0.0051	0.0115 0.0047
(min)	20.9 2.1	54.0 3.8	89.9 7.8	62.5 6.3	64.2 5.1	60.5 3.4
(min)	5 0.6	30 1.9	30 4.7	30 3.1	30 4.5	30 3.9
(ng/mL)	21409.66 754.19	4986.5 254.19	197.13 61.54	1746.92 985.21	1672.15 794.78	420.53 55.69
AUC (min ng/mL)	730484.28 2154.58	380002.28 1733.92	21719.12 997.64	154529.9 453.35	147009.82 656.32	35665.51 188.65
AUC (min ng/mL)	746410.59 2279.59	400032.88 1968.75	26035.83 735.92	165401.58 316.58	157911.56 408.55	38467.34 216.24
(mL/kg)	2028.25 351.81	9741.70 768.37	249246.46 3548.26	27277.96 2159.61	29367.44 2465.91	28376.41 2060.35
CL (mL/min/kg)	66.98 11.43	124.98 20.69	1920.43 451.13	302.29 89.58	316.63 82.56	324.95 61.54
MRT (min)	26.27 8.62	59.54 17.62	79.28 31.94	68.27 19.63	68.59 23.45	63.05 17.62
MRT (min)	28.92 9.02	72.48 20.52	127.44 31.37	85.49 23.92	86.82 25.46	82.30 19.59
(%)	—	53.59	3.48	22.16	21.16	20.6