A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 44

Pharmacokinetic parameters of 8-O-acetyl harpagide and harpagide in rats after oral administration of Ajuga decumbens Thunb. extract () [42].

Compounds	Dose (mg/kg)	(ng/mL)	(h)	(h)	AUC (h/ng/mL)	AUC (h/ng/mL)
8-O-Acetyl harpagide	60	3631. 57299.46	0.33 0.07	2.46 0.25	3539.48 544.05	3822.17 261.30
	30	1383.20 191.25	0.39 0.09	2.88 0.38	1279.56 181.41	1503.31 131.74
	15	502.65 63.27	0.40 0.02	2.74 0.33	883.27 80.03	919.807 5.33
Harpagide	60	844.02 111.48	0.37 0.12	2.77 0.43	1636.18 103.42	1995.30 187.12
	30	496.50 64.21	0.39 0.04	2.67 0.43	866.94 33.36	958.42 110.99
	15	151.81 13.21	0.38 0.12	2.44 0.54	544.70 53.61	614.83 103.28