A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 48

Pharmacokinetic parameters of isoimperatorin after oral administration (25 mg/kg, ) and i.v. injection (dose 5 mg/kg, ) [45].

Parameter	Oral administration		Intravenous administration
	Mean	S.D.	Mean	S.D.
(L/min)	0.028	0.003	—	—
(min)	38.35	7.95	3.64	0.92
(min)	883.15	198.27	44.46	12.25
(L/min)	24.65	4.26	—	—
AUC (μg/mL)·min	364.14	232.18	106.84	23.44
CL(s) (mg/kg/min/μg/mL)	0.069	0.014	0.047	0.012
(min)	49.68	13.36	—	—
(μg/mL)	1.18	0.24	—	—
(mg/kg/μg/mL)	12.10	2.33	—	—
(mg/kg/μg/mL)	—	—	1.26	0.31