A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 50

Pharmacokinetic parameters of all components in rats after oral administration of HMPL-004 (dose 750 mg/kg and ) [47].

Parameters	AND	NAND	DAND	DDAND	CLA	AODG	HM5013620
(h)	3.10 1.92	7.99 7.65	3.15 2.20	2.61 2.43	2.88 3.17	5.96 9.69	3.37 1.65
MRT (h)	4.53 1.49	10.62 10.90	7.21 2.54	3.77 3.13	3.39 1.32	11.62 13.06	5.66 2.17
AUC (h ng/mL)	467.73 102.32	358.48 139.62	232.41 144.07	677.31 261.04	977.88 326.59	613.44 629.80	1378.26 531.08
AUC (h ng/mL)	523.86 134.30	591.79 364.24	291.81 201.35	695.04 187.67	1049.80 283.68	810.21 669.78	1575.12 635.54
(ng/mL)	180.98 71.16	156.73 95.29	62.10 29.00	386.17 100.64	299.67 100.13	98.87 93.19	366.33 86.63
(h)	0.29 0.10	0.29 0.10	0.29 0.10	0.29 0.10	1.71 1.35	6.00 2.19	0.67 0.49