Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 51
Pharmacokinetic parameters of CTX after i.v. and oral administration in rats (
) [
48].
| | Parameters | Intravenous | Oral |
| | AUC (μg h/L) | 1257.6 570.7 | 172.8 118.9 | | AUC (μg h/L) | 1270.1 560.6 | 202.5 123.8 | | MRT (μg h/L) | 0.467 0.056 | 1.2 0.46 | | MRT (μg h/L) | 0.59 0.21 | 2.4 1.8 | | (h) | 1.4 0.76 | 1.7 1.1 | | (h) | — | 0.098 0.040 | | CL/ (L/h/kg) | 22.9 11.2 | 668.7 396.9 | | / (L/kg) | 55.3 54.1 | 1443.2 943.0 | | (μg/L) | 4961.2 3254.8 | 408.8 160.5 | | (%) | — | 3.4 2.4 |
|
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