Review Article
A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 52
Pharmacokinetics of parameters of ailanthone after i.v. administration to rats (
) [
49].
| | Parameters | 0.5 mg/kg | 1 mg/kg | 1.5 mg/kg |
| | (ng/mL) | 813.5 164.6 | 1653.2 98.6 | 2375.3 499.1 | | AUC (min ng/mL) | 23,475.8 4043.7 | 57,874.3 6871.1 | 84,534.5 10,716.0 | | AUC (min ng/mL) | 24,823.1 3975.8 | 61,517.4 5986.2 | 89,176.5 13,481.6 | | (min) | 105.5 13.6 | 113.3 39.6 | 95.8 23.9 | | (mL/kg) | 2955.4 595.7 | 2181.5 518.4 | 2072.1 273.4 | | CL (mL/min/kg) | 20.2 3.6 | 15.8 0.9 | 15.9 2.5 | | MRT (min) | 66.2 5.1 | 61.6 6.2 | 57.7 6.8 |
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