A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 54

Pharmacokinetic parameters of cimicifugosides in rat plasma after oral administration of C. foetida L. extract [51].

Dose (mg/kg)	Compound	AUC (pmol h/mL)	(h)	(pmol/mL)	(h)	(%)
12.5	A	7.72 5.29	0.46 0.36	4.05 3.96	6.74 6.59	1.86
	B	583.3 194.2	2.00 0.78	90.93 38.46	5.77 4.10	26.8
	C	11,350 3500	16.67 5.01	407.1 87.70	11.16 2.31	319
	D	254.9 107.3	8.08 6.86	21.56 8.46	4.69 1.52	48
25	A	0.93 53.19	1.28 1.48	9.36 7.39	2.67 2.33	6.13
	B	2106 428	2.88 1.80	239.4 53.66	3.48 0.55	48.5
	C	16,950 5500	14.67 3.72	713.1 262.0	11.05 1.06	238
	D	349.3 168.5	8.42 7.77	32.66 21.66	4.04 0.66	32.9
50	A	115.9 45.9	0.75 0.66	17.69 12.37	1.46 0.61	6.97
	B	4094 1146	4.67 2.94	395.7 153.9	6.66 3.76	47
	C	35,980 9386	19.67 5.57	1180 262	17.37 8.02	253
	D	804.6 251.2	14.17 6.34	45.09 17.55	4.38 1.08	37.9