A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines
Table 6
Pharmacokinetic parameters of luteolin, apigenin, chrysoeriol, and diosmetin in rats after oral administration of 100 mg/kg FCE with or without coadministration of entacapone (20 mg/kg) [9].
Parameters
Apigenin
Luteolin
FCE
FCE + entacapone
FCE
FCE + entacapone
AUC (mg/L·h)
36.25 16
54.39 24
3.971 1.2
5.862 1.4
MRT (h)
9.46 1.1
9.25 0.9
2.589 0.51
2.585 0.52
(h)
18.44 12
10.98 5.2
2.805 0.9
6.671 7.4
CL/ (L/h/kg)
0.0876 0.060
0.06940 0.046
1.515 0.45
0.818 0.51
/ (L/kg)
2.497 1.5
1.305 0.9
5.975 2.1
4.598 2.8
(mg/L)
3.310 0.73
4.567 1.5
1.684 0.21
2.466 0.69
Parameters
Chrysoeriol
Diosmetin
FCE
FCE + entacapone
FCE
FCE + entacapone
AUC (mg/L·h)
1.468 0.09
1.017 0.17
2.869 0.74
2.329 0.67
MRT (h)
11.07 0.8
10.66 1.1
6.568 0.8
6.869 0.39
(h)
26.24 9
29.80 36
7.359 1.5
7.566 1.6
CL/ (L/h/kg)
1.790 0.60
1.587 0.9
1.773 0.54
2.133 0.50
/ (L/kg)
61.84 12
59.26 50
18.37 5.2
23.58 9
(mg/L)
0.0931 0.028
0.06404 0.025
0.3294 0.052
0.3108 0.074
Data are expressed as mean SD, ; ; compared with the FCE group.
