New Journal of Science / 2016 / Article / Tab 7

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 7

Pharmacokinetic parameters for naringin, hesperidin, neohesperidin, naringenin, and hesperetin after oral administration of Fructus Aurantii extract () [10].

ParameterNaringinHesperidinNeohesperidinNaringeninHesperetin

(ng/mL)279.1 53.8317.04 3.042418.4 72.081088 198.7791.0 165.5
(h)0.28 0.080.25 0.090.28 0.080.42 0.210.42 0.21
(h)9.45 2.883.17 1.218.39 1.454.43 0.604.85 0.51
(L/h) 0.079 0.0220.245 0.0830.085 0.0140.159 0.0190.144 0.016
AUC (ng·h/mL)745.4 304.523.41 7.237985.7 410.87597 27786548 2416
AUC (ng·h/mL)867.1 337.427.33 9.7891111 446.97786 28426760 2474
MRT (h)11.0 1.203.91 0.5110.9 0.5810.4 1.1110.8 0.90
CL/ (L/h-kg)3.09 1.026.31 1.483.41 0.840.012 0.0050.003 0.001
LLOQ (ng/mL)0.500.500.350.500.5