A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 7

Pharmacokinetic parameters for naringin, hesperidin, neohesperidin, naringenin, and hesperetin after oral administration of Fructus Aurantii extract () [10].

Parameter	Naringin	Hesperidin	Neohesperidin	Naringenin	Hesperetin
(ng/mL)	279.1 53.83	17.04 3.042	418.4 72.08	1088 198.7	791.0 165.5
(h)	0.28 0.08	0.25 0.09	0.28 0.08	0.42 0.21	0.42 0.21
(h)	9.45 2.88	3.17 1.21	8.39 1.45	4.43 0.60	4.85 0.51
(L/h)	0.079 0.022	0.245 0.083	0.085 0.014	0.159 0.019	0.144 0.016
AUC (ng·h/mL)	745.4 304.5	23.41 7.237	985.7 410.8	7597 2778	6548 2416
AUC (ng·h/mL)	867.1 337.4	27.33 9.789	1111 446.9	7786 2842	6760 2474
MRT (h)	11.0 1.20	3.91 0.51	10.9 0.58	10.4 1.11	10.8 0.90
CL/ (L/h-kg)	3.09 1.02	6.31 1.48	3.41 0.84	0.012 0.005	0.003 0.001
LLOQ (ng/mL)	0.50	0.50	0.35	0.50	0.5