New Journal of Science / 2016 / Article / Tab 8

Review Article

A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 8

Pharmacokinetic parameters of methoxyflavones after single oral and i.v. 250 mg/kg dose of KP in rats [11].

ParametersRoutePMFTMFDMF

AUC (h·g/mL)Oral3.65 0.636.96 1.117.01 1.37
IV76.77 19.50275.66 86.06233.48 71.57
(h)Oral3.12 1.345.04 1.105.85 1.72
IV2.36 1.894.19 1.453.75 1.01
(h−1)Oral0.28 0.170.15 0.040.13 0.03
IV0.61 0.220.32 0.120.32 0.11
CL (mL/h) Oral622.85 114.86337.00 62.17367.28 82.35
IV21.56 7.186.30 2.177.98 2.34
(h)Oral1.71 0.360.85 0.400.76 0.40
(μg/mL)Oral0.55 0.050.88 0.110.78 0.11
(mL)Oral2637.13 846.592385.10 364.372957.53 458.19
(h−1)Oral1.23 0.548.53 3.648.69 2.33
Bioavailability (%)3.321.752.10
LOD (g/mL)0.19 0.09 0.93
LOQ (g/mL)0.370.191.86

Data are expressed as mean SD (). IV, intravenous. Polyethylene glycol 400: significance higher than the others in the same route at . Significance lower than the others in the same route, . Significance lower than the other route.