A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines

Table 9

Tissue contents in various rat organs after oral administration of 750 mg/kg KP [11].

Organ	Methoxyflavone	Parameter
		AUC (h·μg/g organ)	(μg/g organ)	(h)
Liver	PMF	9.07 1.37	3.10 1.78	3.43 0.98
	TMF	7.83 0.33	3.01 1.49	2.64 1.38
	DMF	8.60 1.97	3.85 1.45	2.57 1.10
Kidney	PMF	2.03 0.67	1.00 0.39	13.43 0.98
	TMF	3.01 0.85	1.64 0.59	3.43 0.98
	DMF	2.51 0.68	1.33 0.49	3.43 0.98
Lung	PMF	1.60 0.37	2.23 1.13	0.08 0.17
	TMF	1.88 0.35	1.41 0.58	1.76 0.19
	DMF	2.17 0.31	2.00 1.20	1.20 0.19
Brain	PMF	0.76 0.13	0.26 0.10	3.14 1.07
	TMF	2.50 0.37	1.43 0.58	3.43 0.98
	DMF	1.91 0.56	0.96 0.37	3.14 1.07
Testes	PMF	1.01 0.24	0.50 0.31	2.36 1.25
	TMF	1.96 0.67	1.10 0.43	3.14 1.07
	DMF	1.90 0.62	10.91 0.44	2.86 1.07

Data are mean SD (). Significance lower than TMF at . Significance lower than DMF at . Significance lower than that of TMF and DMF at . Significance higher than that of TMF and DMF at .