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Neural Plasticity
Volume 9 (2002), Issue 4, Pages 249-254

Long-Term Recording of LTP in Cultured Hippocampal Slices

1Tensor Biosciences, Irvine 92612, CA, USA
2Panasonic Technology Company, 6550 Katella Ave., Cypress 90630, CA, USA
3Dept. Psychiatry and Human Behavior, University of California, 101 Theory Dr., suite 250, Irvine 92697, CA, USA

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.