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Neural Plasticity
Volume 12 (2005), Issue 4, Pages 299-310

Genetic Mouse Models of Alzheimer's Disease

1Yale School of Medicine, Department of Psychiatry, 34 Park Street, 3rd Floor Research, New Haven 06508, CT, USA
2Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
3Laboratoire de Neurosciences Cognitives, UMR 5106, 4SGDP Centre, Talence, France
4Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the current minireview, we focus on genetic mouse models of Alzheimer's disease (AD). Because various excellent, up-to-date reviews, special issues, and reliable websites are already dedicated to the genetics of Alzheimer's disease in general and of animal models in particular, this review is not meant to be comprehensive. Rather, we aim to steer the Alzheimer's novice through the recent mouse literature on AD. Special attention will be paid to genetic models that have been tested behaviorally.