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Neural Plasticity
Volume 2007, Article ID 13427, 6 pages
http://dx.doi.org/10.1155/2007/13427
Research Article

Upregulation of Neurotrophic Factors Selectively in Frontal Cortex in Response to Olfactory Discrimination Learning

1Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84170, Israel
2Faculty of Science and Science Education, Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel

Received 10 December 2006; Accepted 29 March 2007

Academic Editor: Oliver Stork

Copyright © 2007 Ari Naimark et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Hyman, M. Hofer, and Y.-A. Barde et al., “BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra,” Nature, vol. 350, no. 6315, pp. 230–232, 1991. View at Publisher · View at Google Scholar · View at PubMed
  2. B. Lom and S. Cohen-Cory, “Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo,” The Journal of Neuroscience, vol. 19, no. 22, pp. 9928–9938, 1999.
  3. A. K. McAllister, “Subplate neurons: a missing link among neurotrophins, activity, and ocular dominance plasticity?,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 24, pp. 13600–13602, 1999. View at Publisher · View at Google Scholar
  4. A. Shimada, C. A. Mason, and M. E. Morrison, “TrkB signaling modulates spine density and morphology independent of dendrite structure in cultured neonatal Purkinje cells,” The Journal of Neuroscience, vol. 18, no. 21, pp. 8559–8570, 1998.
  5. T. A. Yacoubian and D. C. Lo, “Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth,” Nature Neuroscience, vol. 3, no. 4, pp. 342–349, 2000. View at Publisher · View at Google Scholar · View at PubMed
  6. L. C. Rutherford, S. B. Nelson, and G. G. Turrigiano, “BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses,” Neuron, vol. 21, no. 3, pp. 521–530, 1998. View at Publisher · View at Google Scholar
  7. C. Vicario-Abejón, C. Collin, R. D. G. McKay, and M. Segal, “Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons,” The Journal of Neuroscience, vol. 18, no. 18, pp. 7256–7271, 1998.
  8. F. J. Seil and R. Drake-Baumann, “TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis,” The Journal of Neuroscience, vol. 20, no. 14, pp. 5367–5373, 2000.
  9. P. V. Nguyen and E. R. Kandel, “A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices,” The Journal of Neuroscience, vol. 16, no. 10, pp. 3189–3198, 1996.
  10. P. T. Pang and B. Lu, “Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF,” Ageing Research Reviews, vol. 3, no. 4, pp. 407–430, 2004. View at Publisher · View at Google Scholar · View at PubMed
  11. S.-W. Ying, M. Futter, and K. Rosenblum et al., “Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis,” The Journal of Neuroscience, vol. 22, no. 5, pp. 1532–1540, 2002.
  12. K. Rosenblum, M. Futter, and K. Voss et al., “The role of extracellular regulated kinases I/II in late-phase long-term potentiation,” The Journal of Neuroscience, vol. 22, no. 13, pp. 5432–5441, 2002.
  13. I. Brosh and E. Barkai, “Learning-induced long-term synaptic modifications in the olfactory cortex,” Current Neurovascular Research, vol. 1, no. 4, pp. 389–395, 2004. View at Publisher · View at Google Scholar
  14. D. Saar, Y. Grossman, and E. Barkai, “Reduced synaptic facilitation between pyramidal neurons in the piriform cortex after odor learning,” The Journal of Neuroscience, vol. 19, no. 19, pp. 8616–8622, 1999.
  15. D. Saar, Y. Grossman, and E. Barkai, “Learning-induced enhancement of postsynaptic potentials in pyramidal neurons,” Journal of Neurophysiology, vol. 87, no. 5, pp. 2358–2363, 2002.
  16. S. Knafo, F. Libersat, and E. Barkai, “Dynamics of learning-induced spine redistribution along dendrites of pyramidal neurons in rats,” European Journal of Neuroscience, vol. 21, no. 4, pp. 927–935, 2005. View at Publisher · View at Google Scholar · View at PubMed
  17. S. Knafo, Y. Grossman, E. Barkai, and G. Benshalom, “Olfactory learning is associated with increased spine density along apical dendrites of pyramidal neurons in the rat piriform cortex,” European Journal of Neuroscience, vol. 13, no. 3, pp. 633–638, 2001. View at Publisher · View at Google Scholar
  18. S. Knafo, F. Libersat, and E. Barkai, “Olfactory learning-induced morphological modifications in single dendritic spines of young rats,” European Journal of Neuroscience, vol. 21, no. 8, pp. 2217–2226, 2005. View at Publisher · View at Google Scholar · View at PubMed
  19. D. Saar, Y. Grossman, and E. Barkai, “Long-lasting cholinergic modulation underlies rule learning in rats,” The Journal of Neuroscience, vol. 21, no. 4, pp. 1385–1392, 2001.
  20. U. Staubli, D. Fraser, R. Faraday, and G. Lynch, “Olfaction and the “data” memory system in rats,” Behavioral Neuroscience, vol. 101, no. 6, pp. 757–765, 1987. View at Publisher · View at Google Scholar
  21. U. Staubli, D. Fraser, M. Kessler, and G. Lynch, “Studies on retrograde and anterograde amnesia of olfactory memory after denervation of the hippocampus by entorhinal cortex lesions,” Behavioral and Neural Biology, vol. 46, no. 3, pp. 432–444, 1986. View at Publisher · View at Google Scholar
  22. I. Zelcer, H. Cohen, G. Richter-Levin, T. Lebiosn, T. Grossberger, and E. Barkai, “A cellular correlate of learning-induced metaplasticity in the hippocampus,” Cerebral Cortex, vol. 16, no. 4, pp. 460–468, 2006. View at Publisher · View at Google Scholar · View at PubMed
  23. S. Knafo, G. Ariav, E. Barkai, and F. Libersat, “Olfactory learning-induced increase in spine density along the apical dendrites of CA1 hippocampal neurons,” Hippocampus, vol. 14, no. 7, pp. 819–825, 2004. View at Publisher · View at Google Scholar · View at PubMed
  24. E. M. Quinlan, D. Lebel, I. Brosh, and E. Barkai, “A molecular mechanism for stabilization of learning-induced synaptic modifications,” Neuron, vol. 41, no. 2, pp. 185–192, 2004. View at Publisher · View at Google Scholar
  25. P. B. Shieh and A. Ghosh, “Molecular mechanisms underlying activity-dependent regulation of BDNF expression,” Journal of Neurobiology, vol. 41, no. 1, pp. 127–134, 1999. View at Publisher · View at Google Scholar
  26. H. Thoenen, “Neurotrophins and activity-dependent plasticity,” Progress in Brain Research, vol. 128, pp. 183–191, 2000. View at Publisher · View at Google Scholar
  27. J. P. Kesslak, V. So, J. Choi, C. W. Cotman, and F. Gomez-Pinilla, “Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance?,” Behavioral Neuroscience, vol. 112, no. 4, pp. 1012–1019, 1998. View at Publisher · View at Google Scholar
  28. J. Hall, K. L. Thomas, and B. J. Everitt, “Rapid and selective induction of BDNF expression in the hippocampus during contextual learning,” Nature Neuroscience, vol. 3, no. 6, pp. 533–535, 2000. View at Publisher · View at Google Scholar · View at PubMed
  29. W. Tokuyama, H. Okuno, T. Hashimoto, Y. X. Li, and Y. Miyashita, “BDNF upregulation during declarative memory formation in monkey inferior temporal cortex,” Nature Neuroscience, vol. 3, no. 11, pp. 1134–1142, 2000. View at Publisher · View at Google Scholar · View at PubMed
  30. M. J. M. Schaaf, J. O. Workel, H. M. Lesscher, E. Vreugdenhil, M. S. Oitzl, and E. R. de Kloet, “Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats,” Brain Research, vol. 915, no. 2, pp. 227–233, 2001. View at Publisher · View at Google Scholar
  31. K. D. Broad, M. L. Mimmack, E. B. Keverne, and K. M. Kendrick, “Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory,” European Journal of Neuroscience, vol. 16, no. 11, pp. 2166–2174, 2002. View at Publisher · View at Google Scholar