Research Article

Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex

Figure 8

Blockade of D1, but not D2, receptors prevents the dopamine-induced reduction in input resistance. (a) Bath-application of the D1 receptor antagonist SCH23390 (50  M) prevented the reduction in input resistance induced by 50  M dopamine. Traces at left show voltage responses to a series of current steps during baseline recordings in SCH23390 and during subsequent dopamine application. Traces at right compare the initial voltage responses to −200 pA steps before and after dopamine application. Note that input resistance is unchanged when D1 receptors are blocked. (b) The D2 receptor blocker sulpiride (50  M) does not prevent changes in input resistance induced by dopamine (*, ).
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203514.fig.008b