Dopaminergic Suppression of Synaptic Transmission in the Lateral Entorhinal Cortex
Figure 8
Blockade of D1,
but not D2, receptors prevents the dopamine-induced reduction in
input resistance. (a) Bath-application of the
D1 receptor antagonist SCH23390 (50 M) prevented the reduction in
input resistance induced by 50 M dopamine. Traces at left show voltage responses to a series of current steps
during baseline recordings in SCH23390 and during subsequent dopamine
application. Traces at right compare the initial voltage responses to −200 pA
steps before and after dopamine application. Note that input resistance is unchanged when D1 receptors are
blocked. (b) The D2 receptor blocker sulpiride (50 M) does
not prevent changes in input resistance induced by dopamine (*,).