The Role of -Containing Kainate Receptors in Entorhinal Cortex Gamma Frequency Oscillations
Figure 6
Blocking homomeric GLUK5-containing
KARs significantly reduces kainate-driven gamma frequency oscillations in the MEC. (a) Extracellular field recordings showing 1
second epochs of activity (i) in the presence of 400 nM kainate and (ii)
following application of 10 μM NS3763.
(b) Pooled power spectra (n = 8)
produced from 60 second epochs of extracellular field recorded data, showing a
control recording (black), recording in the presence of 400 nM kainate (blue),
application of 10 μM
NS3763 (green), and a washout back into 400 nM kainate (red). Scale bar represents 200 milliseconds and 100 μV.
