Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats
Figure 3
Decrease in
locomotion following microinjection of deltorphin into the vPAG. Microinjection
of deltorphin (1 μg/0.5 μl) into the vPAG caused a decrease in locomotion in
rats pretreated with morphine (N = 13 and 9 for rats pretreated with 10 and 20 mg/kg) compared to rats pretreated with saline (N = 11). This decrease in
activity is caused by a change in normal behavior to lying and crouching in the
cage following deltorphin administration (see Table 1).