High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

Table 2

Summary of Changes in OCD and BDD in the ten observation periods.

OP1	On-glycine 203 days	Partial reduction of OCD and BDD. Partial elimination of housebound state. Increased mirror tolerance. Barbershop haircuts. Partial resumption of social life. Attendance at social gatherings at homes of family friends. Increased volition and study effort. Obtained GED diploma. Improved hygiene and attention to clothes. Sleep cycle spontaneously normalized.
OP2	Off-glycine 41 days	Partial loss of OP1 gains following infection with high fever. New hand washing ritual based on fear of harm with mild impairment.
OP3	On-glycine 127 days	Rapid recovery from relapse in OP2 and further improvements in OCD and BDD beyond those of OP1. Attended preparatory course for SAT.
OP4	Off-glycine 40 days	No significant change in OCD or BDD.
OP5	On-glycine 137 days	Further reduction in both OCD and BDD. Resumption of normal family social life in home for first time in 8 years. Preparation for SAT by self-study. Excellent SAT scores greatly increased from initial practice test scores (see section on cognition). Housebound state eliminated but community movement remained partially restricted. Improvements resistant to stress and disappointment. Hand washing ritual that started in OP2 disappeared by end of OP5.
OP6	Off-glycine 220 days	Entered college at beginning of this period. In-class socialization with peers. Good academic performance except for apparent cognitive decline after 21-26 weeks (see section on cognition). No significant change in BDD. Increased somatic/cognitive preoccupations with mild impairment. After 10 weeks, a mild increase in line-crossing obsession.
OP7	On-glycine 254 days	Transferred to more competitive college. Consistent academic effort with respectable grades. Major reduction in OCD/BDD. No sensitivity to crime reports in news and increased community mobility. Resumed hair combing in front of mirrors with partially covered face. Father-related BDD by proxy disappeared. Improved family socialization and more order at home. Somatic/cognitive preoccupations remained mild. Gains resistant to stress.
OP8	Off-glycine 46 days	No significant change in OCD or BDD.
OP9	On-glycine 332 days	Very high grades. Developed career ambition. Largely complete remission of line-crossing obsession. Full community mobility and socialization with peers. First date with a girlfriend in 13 years. Reduced self-related BDD and mother-related BDD by proxy. Reduction of somatic/cognitive preoccupations towards end of this period. Improved orderliness at home.
OP10	Off-glycine 541 days	Increase in self-related BDD and in mother-related BDD by proxy caused difficulties in social interactions with mother, relatives, and family friends. Reduction in community mobility due to partial return of major line-crossing obsession. Return of difficulty in making eye contact during greetings and conversations. Reduced volition and orderliness at home. Partial relapse of OCD and BDD occurred very slowly. Major decline in selective aspects of cognition relative to OP5.