Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain
Figure 3
Projection from neurosphere-derived cells towards the lesioned entorhino-hippocampal formation. (a) A strong transplant-derived GFP-positive fiber bundle extends towards the dentate gyrus of the hippocampus in the area of the outer molecular layer. Scale bar = 50 m. (b) Combined image of GFP and SMI-31 confirms that the GFP-expressing fiber bundle (arrow) contains SMI-31-positive axons. (c) High magnification of GFP-positive fibers (arrow) from the transplant in the area of the hippocampal fissure and the outer molecular layer of the dentate gyrus. Scale bar = 100 m. (d) SMI-31 staining of GFP-positive fibers (arrow) from the transplant.
