Neural Plasticity / 2009 / Article / Fig 3

Research Article

Directed Fiber Outgrowth from Transplanted Embryonic Cortex-Derived Neurospheres in the Adult Mouse Brain

Figure 3

Projection from neurosphere-derived cells towards the lesioned entorhino-hippocampal formation. (a) A strong transplant-derived GFP-positive fiber bundle extends towards the dentate gyrus of the hippocampus in the area of the outer molecular layer. Scale bar = 50  m. (b) Combined image of GFP and SMI-31 confirms that the GFP-expressing fiber bundle (arrow) contains SMI-31-positive axons. (c) High magnification of GFP-positive fibers (arrow) from the transplant in the area of the hippocampal fissure and the outer molecular layer of the dentate gyrus. Scale bar = 100  m. (d) SMI-31 staining of GFP-positive fibers (arrow) from the transplant.

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