Review Article

Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

Table 1

Selective vulnerability of synaptic connections between entorhinal layer II neurons and their targets in the hippocampus across different species during aging and in models relevant to Alzheimer’s disease. In this table, “cognitive aging” refers to studies where correlations with memory deficits were observed in aged populations, while “aging” refers to studies comparing across different time points without behavioral assessment. PP: perforant path; DG: dentate gyrus; APP: amyloid precursor protein.

SpeciesNature of deficitVulnerable synapsesReference

HumanCognitive agingPP > DG/CA3[1]
MonkeyAgingPP > DG[44]
DogAgingPP > DG[45]
RatCognitive agingPP > CA3[46]
MouseAgingPP > DG[47]
MouseAPP mutation (Tg2576)PP > DG[48]
MouseAPP mutation (PDAPP) PP > DG[49]