Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
Neurturin-induced activation of KCC2 proximal promoter region. (a) Schematic drawing of the luciferase construct carrying the KCC2 proximal promoter region. The construct contains the luciferase reporter gene under control of a short (309 bp) upstream proximal part of the KCC2 promoter sequence. (b) Normalized luciferase activity 2–4 hours after application of 50 ng/mL Neurturin in div7 hippocampal neuronal cultures transfected with the KCC2 (−309/+42) construct (; **). Error bars represent SEM.
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