Table of Contents Author Guidelines Submit a Manuscript
Neural Plasticity
Volume 2011, Article ID 871296, 9 pages
http://dx.doi.org/10.1155/2011/871296
Review Article

Cortical Plasticity during Motor Learning and Recovery after Ischemic Stroke

1Clinical Neurorehabilitation, Department of Neurology, University of Zurich, 8091 Zurich, Switzerland
2Rehabilitation Institute and Technology Center (RITZ), 8008 Zurich, Switzerland
3Division of Brain Injury Outcomes, Department of Neurology, Johns Hopkins University, Baltimore, MD 21231, USA

Received 21 April 2011; Revised 18 July 2011; Accepted 22 August 2011

Academic Editor: Anja Gundlfinger

Copyright © 2011 Jonas A. Hosp and Andreas R. Luft. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [70 citations]

The following is the list of published articles that have cited the current article.

  • Yuchen Xu, Kedi Xu, Hao Lyu, Stephanie Ng, Wai Sang Poon, Shaomin Zhang, Xiaoling Hu, and Yongping Zheng, “The Effects of EMG Based Fatigue-Controlled and Forced Exercise on Motor Function Recovery: A Pilot Study,” 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER), pp. 25–28, . View at Publisher · View at Google Scholar
  • André J. Szameitat, Shan Shen, Adriana Conforto, and Annette Sterr, “Cortical activation during executed, imagined, observed, and passive wrist movements in healthy volunteers and stroke patients,” NeuroImage, vol. 62, no. 1, pp. 266–280, 2012. View at Publisher · View at Google Scholar
  • A.S. Pagnussat, F. Simao, J.R. Anastacio, R.G. Mestriner, S.M. Michaelsen, C.Canal Castro, C. Salbego, and C.A. Netto, “Effects of skilled and unskilled training on functional recovery and brain plasticity after focal ischemia in adult rats,” Brain Research, vol. 1486, pp. 53–61, 2012. View at Publisher · View at Google Scholar
  • Philipp Mergenthaler, and Andreas Meisel, “Do stroke models model stroke?,” Disease Models & Mechanisms, vol. 5, no. 6, pp. 718–725, 2012. View at Publisher · View at Google Scholar
  • Dong Wan, Hui-Feng Zhu, Yong Luo, and Peng Xie, “Effects of catalpol on the inhibitory microenvironment for axon regeneration in sensorimotor cortex in rats after focal cerebral ischemia,” Chinese Pharmacological Bulletin, vol. 28, no. 10, pp. 1370–1375, 2012. View at Publisher · View at Google Scholar
  • Naoyuki Takeuchi, and Shin-Ichi Izumi, “Maladaptive Plasticity for Motor Recovery after Stroke: Mechanisms and Approaches,” Neural Plasticity, vol. 2012, pp. 1–9, 2012. View at Publisher · View at Google Scholar
  • Francesca Trojsi, Maria Rosaria Monsurrò, Fabrizio Esposito, and Gioacchino Tedeschi, “Widespread Structural and Functional Connectivity Changes in Amyotrophic Lateral Sclerosis: Insights from Advanced Neuroimaging Research,” Neural Plasticity, vol. 2012, pp. 1–13, 2012. View at Publisher · View at Google Scholar
  • Naoyuki Takeuchi, and Shin-Ichi Izumi, “Noninvasive brain stimulation for motor recovery after stroke: Mechanisms and future views,” Stroke Research and Treatment, 2012. View at Publisher · View at Google Scholar
  • Naoyuki Takeuchi, Yutaka Oouchida, and Shin-Ichi Izumi, “Motor Control and Neural Plasticity through Interhemispheric Interactions,” Neural Plasticity, vol. 2012, pp. 1–13, 2012. View at Publisher · View at Google Scholar
  • Young-A Lee, and Yukiori Goto, “The effects of prenatal and postnatal environmental interaction: Prenatal environmental adaptation hypothesis,” Journal of Physiology-Paris, 2013. View at Publisher · View at Google Scholar
  • Sarah R. Hulme, Owen D. Jones, and Wickliffe C. Abraham, “Emerging roles of metaplasticity in behaviour and disease,” Trends in Neurosciences, 2013. View at Publisher · View at Google Scholar
  • Takashi Iida, Osamu Komiyama, Ryoko Obara, Lene Baad-Hansen, Misao Kawara, and Peter Svensson, “Influence of visual feedback on force–EMG curves from spinally innervated versus trigeminally innervated muscles,” Archives of Oral Biology, vol. 58, no. 3, pp. 331–339, 2013. View at Publisher · View at Google Scholar
  • Erin Burke, and Steven C. Cramer, “Biomarkers and Predictors of Restorative Therapy Effects After Stroke,” Current Neurology and Neuroscience Reports, vol. 13, no. 2, 2013. View at Publisher · View at Google Scholar
  • Julia V. Peredeny, and Gary L. Westbrook, “Structural plasticity in the dentate gyrus- revisiting a classic injury model,” Frontiers In Neural Circuits, vol. 7, 2013. View at Publisher · View at Google Scholar
  • Cameron S. Mang, Kristin L. Campbell, Colin J. D. Ross, and Lara A. Boyd, “Promoting Neuroplasticity for Motor Rehabilitation After Stroke: Considering the Effects of Aerobic Exercise and Genetic Variation on Brain-Derived Neurotrophic Factor,” Physical Therapy, vol. 93, no. 12, pp. 1707–1716, 2013. View at Publisher · View at Google Scholar
  • Jonas A. Hosp, and Andreas R. Luft, “Dopaminergic meso-cortical projections to M1: Role in motor learning and motor cortex plasticity,” Frontiers in Neurology, vol. 4, 2013. View at Publisher · View at Google Scholar
  • Yavari, and Towhidkhah, “A new proposal on how motor memory is consolidated,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 25, no. 4, pp. -E4, 2013. View at Publisher · View at Google Scholar
  • Satoshi Ikeda, Akihiko Ohwatashi, Katsuhiro Harada, Yurie Kamikawa, and Akira Yoshida, “Expected for acquisition movement exercise is more effective for functional recovery than simple exercise in a rat model of hemiplegia,” SpringerPlus, vol. 2, no. 1, pp. 1–4, 2013. View at Publisher · View at Google Scholar
  • Naoyuki Takeuchi, and Shin-Ichi Izumi, “Rehabilitation with Poststroke Motor Recovery: A Review with a Focus on Neural Plasticity,” Stroke Research and Treatment, vol. 2013, pp. 1–13, 2013. View at Publisher · View at Google Scholar
  • Wei Li, Tong Han, Wen Qin, Jing Zhang, Huaigui Liu, Ying Li, Liangliang Meng, Xunming Ji, and Chunshui Yu, “Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Well-Recovered Stroke Patients,” Neural Plasticity, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Navid Khodaparast, Seth A. Hays, Andrew M. Sloan, Tabbassum Fayyaz, Daniel R. Hulsey, Robert L. Rennaker, and Michael P. Kilgard, “Vagus Nerve Stimulation Delivered During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke,” Neurorehabilitation and Neural Repair, vol. 28, no. 7, pp. 698–706, 2014. View at Publisher · View at Google Scholar
  • Carsten M. Klingner, Gerd F. Volk, Stefan Brodoehl, Otto W. Witte, and Orlando Guntinas-Lichius, “The effects of deefferentation without deafferentation on functional connectivity in patients with facial palsy,” NeuroImage: Clinical, 2014. View at Publisher · View at Google Scholar
  • Rens Verhagen, Wim L. C. Rutten, and Michel J. A. M. van Putten, “Temporal evolution of event-related desynchronization in acute stroke: A pilot study,” Clinical Neurophysiology, vol. 125, no. 6, pp. 1112–1120, 2014. View at Publisher · View at Google Scholar
  • Yunshuo Tang, Michael P. Stryker, Arturo Alvarez-Buylla, and Juan Sebastian Espinosa, “Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons,” Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 111, no. 51, pp. 18339–18344, 2014. View at Publisher · View at Google Scholar
  • Küper, “Motor rehabilitation of degenerative cerebellar disorders,” Aktuelle Neurologie, vol. 41, no. 5, pp. 294–302, 2014. View at Publisher · View at Google Scholar
  • Jing Sun, Zheng Ke, Shea Ping Yip, Xiao-ling Hu, Xiao-xiang Zheng, and Kai-yu Tong, “Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Dalise, Fabrisia Ambrosio, and Michel Modo, “Adaptive plasticity and recovery in preclinical models of stroke,” Archives Italiennes de Biologie, vol. 152, no. 4, pp. 190–215, 2014. View at Publisher · View at Google Scholar
  • Florinda Ferreri, Guerra, and Rossini, “Neurophysiological markers of plastic brain reorganization following central and peripheral lesions,” Archives Italiennes de Biologie, vol. 152, no. 4, pp. 216–238, 2014. View at Publisher · View at Google Scholar
  • Giuseppe Lamola, Fanciullacci, Rossi, and Chisari, “Clinical evidences of brain plasticity in stroke patients,” Archives Italiennes de Biologie, vol. 152, no. 4, pp. 259–271, 2014. View at Publisher · View at Google Scholar
  • C. Gloor, A.R. Luft, and J.A. Hosp, “Biphasic plasticity of dendritic fields in layer V motor neurons in response to motor learning,” Neurobiology of Learning and Memory, 2015. View at Publisher · View at Google Scholar
  • Maximilian J. Wessel, Maximo Zimerman, and Friedhelm C. Hummel, “Non-invasive brain stimulation: an interventional tool for enhancing behavioral training after stroke,” Frontiers In Human Neuroscience, vol. 9, 2015. View at Publisher · View at Google Scholar
  • Guo-qian He, Wen-ming Xu, Jin-fang Li, Shuai-shuai Li, Bin Liu, Xiao-dan Tan, and Chang-qing Li, “Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells,” Molecular Brain, vol. 8, 2015. View at Publisher · View at Google Scholar
  • Johana A. Gutierrez-Vargas, Alejandro Munera, and Gloria P. Cardona-Gomez, “CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia,” Journal Of Cerebral Blood Flow And Metabolism, vol. 35, no. 12, pp. 1937–1949, 2015. View at Publisher · View at Google Scholar
  • I. N. Angulo-Sherman, A. Costa-García, E. Monge-Pereira, R. Salazar-Varas, and R. Zerafa, “BCI Applied to Neurorehabilitation,” Emerging Therapies in Neurorehabilitation II, vol. 10, pp. 169–196, 2015. View at Publisher · View at Google Scholar
  • M. J. Wessel, M. Zimerman, J. E. Timmermann, K. F. Heise, C. Gerloff, and F. C. Hummel, “Enhancing Consolidation of a New Temporal Motor Skill by Cerebellar Noninvasive Stimulation,” Cerebral Cortex, 2015. View at Publisher · View at Google Scholar
  • Paulo Bazile da Silva, Fabiane Nunes Antunes, Patricia Graef, Fernanda Cechetti, and Aline de Souza Pagnussat, “Strength Training Associated with Task-Oriented Training to Enhance Upper-Limb Motor Function in Elderly Patients with Mild Impairment After Stroke A ,” American Journal Of Physical Medicine & Rehabilitation, vol. 94, no. 1, pp. 11–19, 2015. View at Publisher · View at Google Scholar
  • Lijun Chen, Chuanfu Li, Jian Zhai, Anqin Wang, Qin Song, Ying Liu, Ru Ma, Long Han, Yamikani Ndasauka, Xiaoming Li, Hai Li, and Xiaochu Zhang, “Altered Resting-State Signals in Patients with Acute Stroke In or Under the Thalamus,” Neuroscience Bulletin, 2016. View at Publisher · View at Google Scholar
  • Patricia Graef, Maria Luísa Rocha Dadalt, Daiana Amaral M. da S. Rodrigues, Cinara Stein, and Aline S. Pagnussat, “Effect of transcranial magnetic stimulation combined with upper-limb training for improving function after stroke: A systematic review and meta-analysis,” Journal of the Neurological Sciences, 2016. View at Publisher · View at Google Scholar
  • Arsénio Reis, Jorge Lains, Hugo Paredes, Vitor Filipe, Catarina Abrantes, Fernando Ferreira, Romeu Mendes, Paula Amorim, and João Barroso, “Developing a System for Post-Stroke Rehabilitation: An Exergames Approach,” Universal Access in Human-Computer Interaction. Users and Context Diversity, vol. 9739, pp. 403–413, 2016. View at Publisher · View at Google Scholar
  • Arturo Nuara, Letizia Leocani, Elise Houdayer, Marco Cursi, Sonia Zanini, Roberto Gatti, and Giancarlo Comi, “Cortical motor circuits after piano training in adulthood: Neurophysiologic evidence,” PLoS ONE, vol. 11, no. 6, 2016. View at Publisher · View at Google Scholar
  • Maximilian Schubring-Giese, Susan Leemburg, Andreas Rüdiger Luft, and Jonas Aurel Hosp, “Protein synthesis inhibition in the peri-infarct cortex slows motor recovery in rats,” PLoS ONE, vol. 11, no. 6, 2016. View at Publisher · View at Google Scholar
  • Dae Yul Kim, Erin B. Quinlan, Robert Gramer, and Steven C. Cramer, “BDNF Val(66)Met Polymorphism Is Related to Motor System Function After Stroke,” Physical Therapy, vol. 96, no. 4, pp. 533–539, 2016. View at Publisher · View at Google Scholar
  • Mohit Kothari, Xuemei Liu, Lene Baad-Hansen, Guo Bin, Abhishek Kumar, and Peter Svensson, “Influence of visual observational conditions on tongue motor learning,” European Journal of Oral Sciences, vol. 124, no. 6, pp. 534–539, 2016. View at Publisher · View at Google Scholar
  • B. Hertler, M.M. Buitrago, A.R. Luft, and J.A. Hosp, “Temporal course of gene expression during motor memory formation in primary motor cortex of rats,” Neurobiology of Learning and Memory, vol. 136, pp. 105–115, 2016. View at Publisher · View at Google Scholar
  • Stella M. Michaelsen, Daiana A. M. S. Rodrigues, Aline de Souza Pagnussat, Patrícia Graef, Maria L. R. Dadalt, and Franciele Pereira, “Effects of functional and analytical strength training on upper-extremity activity after stroke: A randomized controlled trial,” Brazilian Journal of Physical Therapy, vol. 20, no. 6, pp. 543–552, 2016. View at Publisher · View at Google Scholar
  • Rocco Salvatore Calabrò, Margherita Russo, Placido Bramanti, Antonino Naro, Demetrio Milardi, Tina Balletta, Antonino Leo, and Serena Filoni, “Who May Benefit From Armeo Power Treatment? A Neurophysiological Approach to Predict Neurorehabilitation Outcomes,” PM and R, vol. 8, no. 10, pp. 971–978, 2016. View at Publisher · View at Google Scholar
  • Gerd F. Volk, Orlando Guntinas-Lichius, Carsten M. Klingner, Stefan Brodoehl, and Otto W. Witte, “Adaptive and maladaptive neural plasticity due to facial nerve palsy: What can we learn from pure deefferentation?,” Zeitschrift fur Psychologie / Journal of Psychology, vol. 224, no. 2, pp. 102–111, 2016. View at Publisher · View at Google Scholar
  • Claudia Alia, Cristina Spalletti, Stefano Lai, Alessandro Panarese, Giuseppe Lamola, Federica Bertolucci, Fabio Vallone, Angelo Di Garbo, Carmelo Chisari, Silvestro Micera, and Matteo Caleo, “Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation,” Frontiers in Cellular Neuroscience, vol. 11, 2017. View at Publisher · View at Google Scholar
  • Manuel Buitrago Blanco, Benjamin Hertler, Jonas Aurel Hosp, and Andreas Rüdiger Luft, “Substance P signalling in primary motor cortex facilitates motor learning in rats,” PLoS ONE, vol. 12, no. 12, 2017. View at Publisher · View at Google Scholar
  • Karin Morandell, and Daniel Huber, “The role of forelimb motor cortex areas in goal directed action in mice,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, and Yves Vandermeeren, “Increased functional connectivity one week after motor learning and tDCS in stroke patients,” Neuroscience, vol. 340, pp. 424–435, 2017. View at Publisher · View at Google Scholar
  • Ilaria Zivi, Eugenio Bertelli, Giacinta Bilotti, Leopold Saltuari, Giuseppe Frazzitta, and Ignazio Alessandro Clemente, “Blink-associated contralateral eccentric saccades as a rare sign of unilateral brain injury,” Neurology, vol. 88, no. 2, pp. 160–163, 2017. View at Publisher · View at Google Scholar
  • Euzébio D. de Souza, and Eduardo José Lima II, “Autonomic Computing in a Biomimetic Algorithm for Robots Dedicated to Rehabilitation of Ankle,” International Journal of Grid and High Performance Computing, vol. 9, no. 1, pp. 48–60, 2017. View at Publisher · View at Google Scholar
  • Takashi Nakajima, “VIII. Cybernic treatment for the neuromuscular diseases,” Nihon Naika Gakkai Zasshi, vol. 107, no. 8, pp. 1507–1513, 2018. View at Publisher · View at Google Scholar
  • Carolina C. Alcantara, Luisa F. García-Salazar, Marcela A. Silva-Couto, Gabriela L. Santos, Darcy S. Reisman, and Thiago L. Russo, “Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review,” Frontiers in Neurology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Zenas C Chao, Masahiro Sawada, Tadashi Isa, and Yukio Nishimura, “Dynamic Reorganization of Motor Networks During Recovery from Partial Spinal Cord Injury in Monkeys,” Cerebral Cortex, 2018. View at Publisher · View at Google Scholar
  • Yingli Wang, Zhaohui Zhang, Lei Zhang, Haoran Yang, and Zhiqiang Shen, “RLIPostC protects against cerebral ischemia through improved synaptogenesis in rats,” Brain Injury, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Ritika Suri, Federico Rodriguez-Porcel, Kelly Donohue, Erin Jesse, Lilia Lovera, Alok Kumar Dwivedi, and Alberto J. Espay, “Post-stroke Movement Disorders: The Clinical, Neuroanatomic, and Demographic Portrait of 284 Published Cases,” Journal of Stroke and Cerebrovascular Diseases, 2018. View at Publisher · View at Google Scholar
  • A. T. O'Brien, F. Bertolucci, G. Torrealba-Acosta, R. Huerta, F. Fregni, and A. Thibaut, “Non-invasive brain stimulation for fine motor improvement after stroke: a meta-analysis,” European Journal of Neurology, 2018. View at Publisher · View at Google Scholar
  • Rocco Salvatore Calabrò, Antonino Naro, Margherita Russo, Placido Bramanti, Luigi Carioti, Tina Balletta, Antonio Buda, Alfredo Manuli, Serena Filoni, and Alessia Bramanti, “Shaping neuroplasticity by using powered exoskeletons in patients with stroke: a randomized clinical trial,” Journal of NeuroEngineering and Rehabilitation, vol. 15, no. 1, 2018. View at Publisher · View at Google Scholar
  • Maximilian Jonas Wessel, Kshitij Sharma, Francesco Mondada, Pierre Dillenbourg, Arzu Guneysu Ozgur, Wafa Johal, Ayberk Zgür, Philippe Vuadens, and Friedhelm Christoph Hummel, “Iterative Design of an Upper Limb Rehabilitation Game with Tangible Robots,” ACM/IEEE International Conference on Human-Robot Interaction, pp. 241–250, 2018. View at Publisher · View at Google Scholar
  • Lina Bunketorp Käll, Robert J. Cooper, Johanna Wangdell, Jan Fridén, and Malin Björnsdotter, “Adaptive motor cortex plasticity following grip reconstruction in individuals with tetraplegia,” Restorative Neurology and Neuroscience, vol. 36, no. 1, pp. 73–82, 2018. View at Publisher · View at Google Scholar
  • Erin Burke Quinlan, Lucy Dodakian, Jill See, Alison McKenzie, Jill Campbell Stewart, and Steven C. Cramer, “Biomarkers of Rehabilitation Therapy Vary according to Stroke Severity,” Neural Plasticity, vol. 2018, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Eugeniia V. Ekusheva, and A. A. Komazov, “Disorders of fine motor skills after a stroke: the processes of neuroplasticity and sensorimotor integration,” Journal of Clinical Practice, vol. 10, no. 1, pp. 16–22, 2019. View at Publisher · View at Google Scholar
  • Natalia Brandwayn, David Restrepo, Adriana Marcela Martinez-Martinez, and Cesar Acevedo-Triana, “Effect of fine and gross motor training or motor imagery, delivered via novel or routine modes, on cognitive function,” Applied Neuropsychology: Adult, pp. 1–18, 2019. View at Publisher · View at Google Scholar
  • Yinan Chen, Song Wu, Zhengting Tang, Jinglu Zhang, Lin Wang, Linfeng Yu, Kelun Wang, and Peter Svensson, “Effects of Motor Training on Accuracy and Precision of Jaw and Finger Movements,” Neural Plasticity, vol. 2019, pp. 1–11, 2019. View at Publisher · View at Google Scholar
  • Takashi R Sato, Takahide Itokazu, Hironobu Osaki, Makoto Ohtake, Tetsuya Yamamoto, Kazuhiro Sohya, Takakuni Maki, and Tatsuo K Sato, “Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex,” eLife, vol. 8, 2019. View at Publisher · View at Google Scholar
  • Gustavo Balbinot, and Clarissa Pedrini Schuch, “Compensatory Relearning Following Stroke: Cellular and Plasticity Mechanisms in Rodents,” Frontiers in Neuroscience, vol. 12, 2019. View at Publisher · View at Google Scholar
  • Li-Mei Cao, Zhi-Qiang Dong, Qiang Li, and Xu Chen, “Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats,” Neural Regeneration Research, vol. 14, no. 8, pp. 1387, 2019. View at Publisher · View at Google Scholar
  • Euzébio D. de Souza, and Eduardo José Lima II, “Autonomic Computing in a Biomimetic Algorithm for Robots Dedicated to Rehabilitation of Ankle,” Robotic Systems, pp. 955–968, 2020. View at Publisher · View at Google Scholar