Review Article

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics

Figure 1

HSA21 (with main cytogenetic bands) and its ortholog segments in the mouse genome (MMU16, MMU17 and MMU10) are indicated. Main mouse models and those reported in this review are indicated in black for human genes, and in gray for mouse genes. Models with cDNA constructs are indicated in italics. Representation of their localisation is not to scale. Tc1 [32]; TghAPP [33]; TgSYNJ1 [54]; TgITSN1 [55]; TgRCAN1-L [56]; TgYAC152F7 [34]; hBACTgDYRK1A [24]; TgPCP4 [38]; TghCBS60.4 [57]; Ts65Dn [22]; Ts1Cje [23]; Ts1RhR [58]; TgSynj1 [54]; TgDyrk1a [59]; mBACTgDyrk1a [25]; Dup(16)Yu, Dup(17)Yu and Dup(10)Yu [29, 31]; Ts1Yah [30].
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