Intracellular Ca2+ Stores and Ca2+ Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release
Figure 4
Inhibiting TRPC channels prevented the BDNF-induced increase in mEPSC frequency. Top: representative trace from a CA1 pyramidal cell in the presence of the SOC/TRPC channel inhibitor SKF96365 (30 μM) prior to and following BDNF application; left: representative running average plot of mEPSC frequency in the presence of SKF96365; right: mean frequency of mEPSCs before and after BDNF in the continuous presence of SKF96365.
