Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior
Figure 3
Heroin self-administration and extinction in GFAP-tk mice implanted with minipumps containing either saline or GCV. (a) Active lever presses during 10 days of heroin self-administration followed by 5 days of extinction. Mice treated with GCV () displayed increased extinction responding during the first 3 extinction days (E1–E3) as compared to mice that were treated with saline (). versus saline-treated mice on the same day of extinction. (b) Inactive lever presses during 10 days of heroin self-administration followed by 5 days of extinction.
