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Neural Plasticity
Volume 2012, Article ID 352829, 7 pages
Research Article

SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses

1Cellular & Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, 1919-1, Tancha, Onna 904-0495, Japan
2Molecular Gerontology Research Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), 11 Minamiooya, Machida 194-8511, Japan
3Department of Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan
4Department of Medical Chemistry, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan
5Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 7 Goban-cho, Chiyoda-ku 102-0076, Japan

Received 10 September 2012; Accepted 31 October 2012

Academic Editor: Michael Stewart

Copyright © 2012 Hiroshi Takagi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.