Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

Table 1

Behavioral phenotypes of mouse models.

Human chromosomal region	Behavioral phenotypes	Reference
7q11.23 (deletion)	Increased sociability	[9]
	Increased acoustic startle response
	Cognitive deficits
	Growth retarded (male)
15q11-13 (duplication)	Decreased sociability	[10, 11]
	Behavioral inflexibility
	abnormal ultrasonic vocalizations
	decreased spontaneous activity
	Increased anxiety
16p11.2 (deletion)	Hyperactive	[12]
	difficulty adapting to change
	sleeping abnormalities
	repetitive or restricted behaviors
16p11.2 (duplication)	Hypoactive	[12]
17p11.2 (deletion)	cranio facial abnormalities	[13]
	Seizures
	Obesity
22q11.21 (deletion)	Deficits in sensorimotor gating	[14, 15]
	Working memory deficit
	Deficit in both cued and contextual fear memory