Dissociation of spine size and synaptic strength. (a) The release of glutamate was reduced for 48 hours specifically on the spine marked (1). This leads to a homeostatic enhancement of synaptic strength, as assessed by 2P-uncaging of MNI-Glutamate. The size of the synaptic currents induced by 2P-uncaging is shown in the bottom panel. (b) The significant enhancement of the amplitude of synaptic currents onto “silenced” spines was not accompanied by any measurable changes in spine volume. Adapted from [15].
