Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases

Table 1

Kalirin and human diseases.

Kalirin isoform	Disease	Physiological relevance	References
Kalirin-7 (Duo)	Schizophrenia	Decreased spine density, decreased Kalirin-7 mRNA levels in the prefrontal cortex	[24]
Kalirin (unknown isoforms)	Schizophrenia	Kalirin mRNA increases 2-fold in the prefrontal cortex	[25]
Kalirin-7	Schizophrenia	DISC1 regulates spine formation via Kal7-Rac1	[10]
Kalirin	Schizophrenia	Kalirin is a risk factor for schizophrenia	[26]
Kalirin-7	Alzheimer’s Disease	Decreased levels of Kalirin-7 mRNA and protein in hippocampus	[27, 28]
Kalirin (unknown isoforms)	Animal model of depression	Decreased Kalirin expression in the prefrontal cortex and hippocampus. ECT increases Kalirin expression in hippocampus	[29, 30]
Kalirin-7	Animal model of depression	Decreased Kalirin-7 expression in hippocampus	[31]
Kalirin (unknown isoforms)	Animal model of epilepsy	Decreased Kalirin expression in hippocampus	[32]
Kalirin (unknown isoforms)	ADHD	Unknown	[33]
Kalirin (unknown isoforms)	Stroke	Unknown	[34, 35]
Kalirin (unknown isoforms)	Coronary Heart disease	Unknown	[36]
Kalirin (unknown isoforms)	Huntington’s disease	Spectrin-like domains of Kalirin interact with HAP1	[12]
Kalirin-7	Animal model of cocaine addiction	An essential determinant of dendritic spine formation following cocaine treatment	[37, 38]