Adaptive Neuroplastic Responses in Early and Late Hemispherectomized Monkeys
Figure 3
Normal gait was significantly affected by the removal of one hemisphere. The ipsilateral side of the body acts as a control for normal motor movements and did not show any paresis, also referred to as the nonparetic side of the subject. Panels (a)–(d) are indicative of a typical gait sequence. As the forelimb moves forward, the contralateral appendages drag on the ground (arrow panel a). The hand dragging continues through the entire forward motion (arrow panels b and c). The hind limb is fully removed from the ground and does not drag (arrow d). At each time point and lesion group there is a significant effect of the hemispherectomy on upper limb movement defined as arm drags/total forward arm movements (e). A number of abnormal leg movements (drags and limps) as a percentage of total leg movements was significantly elevated over the expected rate of zero in the adult-lesioned group only (f). Years 1, 2, and 3 refer to the age of the infant-lesioned subjects at testing which also corresponds to the years after lesion. For the adult-lesioned subjects, testing occurred 3 years after initial surgery when the subjects were 7 years old. * adapted from [14].
