|Species||Susceptibility genes (animal model)||Experimental approach||Effects on neurogenesis||Effects on behavior||References|
|C57BL6/Jmouse||DISC1||Knockdown of Disc1 via retroviral-mediated shRNA approach.||Enhanced dendritic outgrowth, soma hypertrophy, overextended migration, accelerated synapse formation of newborn granule neurons.||NS|||
|C57BL6/Jmouse||DISC1||Knockdown of Disc1 via retroviral-mediated shRNA approach.||Mistargeted axonal mossy fibers and presynaptic differentiation of newborn granule neuron.||NS|||
|C57BL6/Jmouse||DISC1||Knockdown of Disc1 via lentiviral-mediated shRNA approach.|
Proliferation: BrdU (1 × 40 mg/kg, ip) at 2 hours pulsing chase.
|Decreased cell proliferation||Hyperlocomotion in a novel environment.|
|BrdU (50 mg/kg, ip) for 12 days.||Decreased neural progenitors and immature neurons. |
Misoriented apical dendrites on immature neurons.
|Selective impairment in working memory|||
Npas3 null mouse
|Proliferation: BrdU daily (50 mg/kg, ip) for 12 days and analysis on day 13||Decreased cell proliferation in Npas3 null mouse.||Locomotor hyperactivity, subtle gait defects, impairment of prepulse inhibition of acoustic startle, deficit in recognition memory, and altered anxiety-related responses.||[22, 23]|
Overexpression of SREB2 transgenic mouse (Tg)
|Proliferation: BrdU (3 × 100 mg/kg, ip) interval 2 hours apart and analysis on Day 3 after BrdU injection. |
Survival: Three BrdU pulses (100 mg/kg, ip) at 2-hour intervals. Analysis on Day 30 following BrdU injection.
|SREB2 Tg: decreased cell proliferation and neuronal maturation.|
Dendritic morphology deficits in newborn granule neurons.
SREB2 null mouse: no change in cell proliferation, but increased neuronal survival rate.
|SREB2 Tg: decreased discrimination in the spatial pattern separation. |
SREB2 null mouse: enhanced discrimination in the spatial pattern separation.
|C57BL6/Jmouse||Prenatal injection of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid (PolyI:C) into mice||BrdU (100 uL/20 g, ip) daily for 3 days and analysis |
|Decreased neural progenitors.||Behavioral deficits in the open field test and prepulse inhibition of the startle response.||[25, 26]|