Hippocampal CA1 Pyramidal Neurons of Mecp2 Mutant Mice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage
Figure 2
Quantitative analyses of dendritic spines in CA1 pyramidal neurons from Mecp2 mutant mice and age-matched wildtype littermates. (a) Representative examples of apical dendritic segments of CA1 pyramidal neurons from P7 wildtype and mice (top). Scale bar represents 2 μm.(b) Examples of apical dendritic segments of CA1 pyramidal neurons from P15 wildtype and mice (top). (c) Examples of apical dendritic segments of CA1 pyramidal neurons from P40 wildtype and mice (top). (d) Dendritic spine density (spines per 10 μm of dendrite). All data are expressed as mean ± SEM. *indicates P < 0.05.
