Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
Comparison of gene expression profiles between Shn-2 KO mice and individuals with schizophrenia. (a) Scatter plot of gene expression fold change values in the medial prefrontal cortex (mPFC) of Shn-2 KO mice and Brodmann area (BA) 10 of postmortem schizophrenia brain. (b) Genes differentially expressed in both Shn-2 KO mice and in schizophrenia. Red indicates gene upregulation and blue indicates downregulation in both Shn-2 KO mice and in schizophrenia. The top 40 genes with respect to the fold change values are included. Asterisks indicate inflammation-related genes. (c)–(f) The hippocampal transcriptome pattern of Shn-2 KO mice was similar to the transcriptome data from lipopolysaccharide (LPS) treatment ((c), ), injury ((d), ), prion infection ((e), ), and aging ((f), ). Adapted from Takao et al. .