Methylcobalamin: A Potential Vitamin of Pain Killer

Table 3

The analgesic effect of MeCbl or combined with other agents on neuralgia.

Effects of MeCbl	Indices	Measures of intervention	Reference
Reduced or eliminated pain symptoms	Pain scales in patients with trigeminal neuralgia	Intravenous injection of MeCbl at a single dose of 0.5 mg	Teramoto [32]
Relieved overall pain, continuous spontaneous pain, paroxysmal pain, and allodynia	Likert-type pain intensity scale; Patients’ Global Impression of Change (PGIC) scale	Local subcutaneous injection of MeCbl for 4 weeks	Xu et al. [30]
Lowered pain intensities; improved pain relief; reduced pain interference with quality of life	Numerical pain scale and brief pain inventory of glossopharyngeal neuralgia	Oral administration of gabapentin, tramadol, and MeCbl (0.5 mg)	Singh et al. [31]