Neural Plasticity and Proliferation in the Generation of Antidepressant Effects: Hippocampal Implication
Figure 5
Implication on β-catenin subcellular distribution of the chronic (14 days) antidepressant treatment with the SNRI venlafaxine (40 mg/kg/day) (a), and 7-day treatment with the SSRI fluoxetine (5 mg/kg/day), the antagonist ketanserin (0.1 mg/kg/day), and the combination of both (b). Note that chronic treatment with venlafaxine produces an increase in both membrane-associated and nuclear β-catenin, while the subchronic treatment with fluoxetine + ketanserin, only increases β-catenin in the membrane but not in the nuclear fraction. * and *** versus vehicle. (a) Modified from Mostany et al., 2008 [10], and (b) modified from Pilar-Cuellar et al., 2012 [83].
