Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease
Figure 1
Acute MPTP-induced microglial activation in the striatum of adult mice. (a) Microglia in resting condition in control and (b) activated microglia in MPTP treated animals. MPTP was dissolved in physiological saline and administered subcutaneously (s.c.) a dose of 10 mg/kg every 2 hr for a total of 4 injections. Mice were killed 48 h after last injection and processed for immunofluorescence staining. Microglia were labeled with MAC-1 antibody. Scale bar = 400 μm.
