Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Figure 5
Histological markers of radiation injury in the mouse brain at 90, 120, 180, and 300 days after RT. (a, b) Luxol fast blue staining showing loss of myelin. (c, d) Sections of brain nerve fibers showing structural changes, microglial (outlined in green) inflammation, and myelin sheath thickening indicative of cell death (images at 50x). (e, f) Yellow and blue arrow heads point at myelin sheath surrounding the neurons and at mitochondria, respectively (scale bar = 1 m). (g) Necrosis detected at 120 days. (h) Yellow arrows point at pericyte pulling away from endothelial cell, a sign of inflammation, with white edematous area causing vascular constriction.
