Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy
Figure 6
Effect of a single 4 Gy dose of X-ray radiation on microglia in the developing rat brain 24 hr after exposure. (a, b) A schematic representation of microglia distribution (gray dots) in the cerebral cortex showing that RT-induced loss of microglia is more pronounced in inner layers relative to superficial layers. (c, d) Representative 20x images of Iba1+ staining in the retrosplenial cortex showing that RT not only reduces the number of microglia but also alters their morphology.
